Solid dispersion is a unique approach to enhance the solubility and dissolution rate of poorly water soluble drugs. The purpose of the present study was to enhance the dissolution rate of simvastatin (SIM), a practically water insoluble drug by preparation of solid dispersion using a hydrophilic carrier, poloxamer 188 (PXM). The solid dispersions of simvastatin were prepared using techniques such as co-grinding, kneading and solvent evaporation. All the solid dispersions showed an increase in the dissolution rate of simvastatin but the solid dispersion prepared by kneaded method exhibited best dissolution profile. The x-ray diffraction and scanning electron microscopy studies demonstrated that enhanced dissolution of SIM from kneaded solid dispersions might be due to decrease in crystallinity of SIM. The kneaded solid dispersions were formulated into tablets using superdisintegrant Ac-di- sol. Dissolution studies of the tablets were carried out in phosphate buffer pH 6.8. Findings of this study showed that dissolution enhancement of SIM was obtained by preparing its solid dispersions with PXM using kneaded technique.
Loading....